Cisplatin cardiomyopathy
WebJun 1, 2013 · Cardiotoxicity is a well known consequence of cancer chemotherapy. Cisplatin-based combinations are standard regimens in the therapy of advanced non-small cell lung cancer. Administration of cisplatin-containing chemotherapy causes significant oxidative and nitrosative stress in some patients.
Cisplatin cardiomyopathy
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WebJan 1, 2013 · Patients receiving cisplatin-based chemotherapy may experience coronary artery diseases, arrhythmias, and cardiomyopathy 3). Moore et al. have reported cases of arterial thrombosis with subsequent ... WebThis table is provided as an example of how to administer this regimen; there may be other acceptable methods. This regimen must be administered by a clinician trained in the use of chemotherapy, who should use independent medical judgment in the context of individual circumstances to make adjustments, as necessary.
WebThis study has been initiated to investigate whether endogenous carnitine depletion and/or carnitine deficiency is a risk factor during development of cisplatin (CDDP)-induced cardiomyopathy and if so, whether carnitine supplementation by propionyl-L-carnitine (PLC) could offer protection against this toxicity. WebCardiotoxicity has been well documented as a side effect of cisplatin (CDDP) treatment. The inflammatory response plays a crucial role in the pathological process of CDDP-induced cardiotoxicity. Wogonin is a natural flavonoid compound that possesses cardioprotective and anti-inflammatory qualities.
WebNational Center for Biotechnology Information WebMar 12, 2015 · We previously demonstrated that the increase in troponin I (TnI) soon after high-dose chemotherapy (HDC) is a strong predictor of left ventricular dysfunction and poor cardiac outcome, particularly in patients showing a persistent TnI increase. 5,6 This finding has important clinical implications and allows the identification of patients at high risk of …
WebAfter right heart catheterization, pathological results of a myocardial biopsy from the ventricular septum indicated no cardiac muscle hypertrophy, cardiac fibrosis, …
WebChemotherapeutic drugs can cause cardiac toxicities such as cardiomyopathy, arrhythmia, and cardiovascular disease. The well-known side effects of cisplatin are nephrotoxicity, nausea, vomiting, and electrolyte imbalance. Cardiotoxicity induced by cisplatin is rare, and its pathophysiology is unknown. how to stitch a pillow closedWebJun 1, 2024 · Cisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). ... We showed that old mice had more severe kidney injury and cardiomyopathy after exposure to ... react task force santa clara countyWebMar 17, 2024 · Cardiotoxicity is defined as any heart injury (functional or structural) related to cancer treatment, taking into consideration chemotherapy, radiotherapy … how to stitch a longWebJun 23, 2014 · Cardiomyopathy after the use of gemcitabine monotherapy is extremely rare; and only one such case has been reported in detail previously. ... Barton C, Ghahramani P, Hirsh V: Randomized phase II trial of gemcitabine-cisplatin with or without trastuzumab in HER2-positive non-small-cell lung cancer. Ann Oncol. 2004, 15: 19-27. … react talentedWebFeb 2, 2024 · Learn about the potential side effects of pemetrexed. Includes common and rare side effects information for consumers and healthcare professionals. react tcp clientWebOct 1, 2013 · Chemotherapy may induce entire spectrum of cardiac pathology. Cisplatin (CDDP) is a widely used chemotherapeutic agent and its use is limited by its wide range of toxicities, most common being renal and neurotoxicity. Cardiotoxicity of cisplatin is less common and may range from silent and symptomatic arrhythmias to cardiomyopathy … react task schedulerWebCisplatin can induce direct myocardial toxicity leading to atrial fibrillation whereas the potential of myocardial toxicity is amplified when the drug is administered in … react tcp