Phosphopantetheine adenylyltransferase
WebJun 3, 2010 · Phosphopantetheine adenylyltransferase (PPAT) catalyzes the penultimate step in the coenzyme A (CoA) biosynthetic pathway, reversibly transferring an adenylyl group from ATP to 4'-phosphopantetheine (PhP) to form dephosphocoenzyme A. This reaction sits at the branch point between the de novo pathway and the salvage pathway, and has been … WebMar 2, 2024 · Phosphopantetheine Adenylyltransferase: A promising drug target to combat antibiotic resistance. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics …
Phosphopantetheine adenylyltransferase
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Webpantetheine adenylyltransferase (PPAT), which catalyzes the penultimate step in the pathway (Fig. 1), the reversible adeny-lation of 49-phosphopantetheine to form 39 … WebOct 3, 2003 · In coenzyme A, 4′-phosphopantetheine is covalently linked to an adenylyl group, whereas it is covalently linked to a serine hydroxyl group in acyl carrier proteins. 4′-phosphopantetheine is cofactor of enzymes that play a role in the biosynthesis of fatty acids, polypeptide antibiotics, and polyketides ( 2 ).
WebFunction Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. UniRule annotation Catalytic activity (R)-4' … WebApr 4, 1999 · Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in bacteria that catalyses a rate-limiting step in coenzyme A (CoA) biosynthesis, by transferring an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA).
Webpantetheine-phosphate adenylyltransferase Synonyms 3′-dephospho-CoA pyrophosphorylase PPAT dephospho-CoA pyrophosphorylase dephospho-coenzyme A pyrophosphorylase pantetheine phosphate adenylyltransferase Additional information <3, 4> (<3,4> with EC 2.7.1.24 part of a bifunctional enzyme with EC 2.7.1.24 [4,5]) [4, 5] CAS … WebFeb 7, 2024 · Phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis in complex with 3-(1H-indol-3-yl)propanoic acid at 1.6A resolution.
WebIn enzymology, a pantetheine-phosphate adenylyltransferase ( EC 2.7.7.3) is an enzyme that catalyzes the chemical reaction. ATP + 4'-Phosphopantetheine diphosphate + 3' …
WebJan 25, 2002 · Introduction. Phosphopantetheine adenylyltransferase (PPAT) catalyzes a key regulatory step in the coenzyme A (CoA) biosynthetic pathway: 1 the reversible transfer of an adenylyl group from ATP to 4′-phosphopantetheine (Ppant), which yields 3′-dephospho-CoA (dPCoA) and pyrophosphate. 2 CoA biosynthesis occurs in a series of … dft code in matlab defining a windowWebOct 3, 2001 · Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in the coenzyme A pathway that catalyzes the reversible transfer of an adenylyl group from ATP … chuwi freebook 360 ° newsWebJan 25, 2002 · Phosphopantetheine adenylyltransferase (PPAT) catalyzes a key regulatory step in the coenzyme A (CoA) biosynthetic pathway: 1 the reversible transfer of an … chuwi freebook 360 reviewWebMar 24, 2010 · To identify the phosphopantetheine adenylyltransferase sub-site bound by these inhibitors, two techniques were utilized: steady-state enzyme kinetics and a novel 19 F NMR method in which fluorine-containing fragments that bind the ATP and/or phosphopantetheine sites serve as competitive reporter probes. These data are … dft coefficients是什么WebPhosphopantetheine adenylyltransferase (PPAT, EC. 2.7.7.3) catalyzes an essential step in the reaction that transfers an adenylyl group from adenosine tri phosphate (ATP) to 4' … chuwi freebook reviewWebAug 31, 2015 · Inside the cell, 4′-phosphopantetheine was enzymatically converted back to CoA by the bifunctional enzyme CoA synthase. Phenotypes induced by intracellular CoA deprivation were reversed when... chuwi driver windows 11WebSep 1, 1999 · Phosphopantetheine adenylyltransferase (PPAT) catalyzes the penultimate step in coenzyme A (CoA) biosynthesis: the reversible adenylation of 4'-phosphopantetheine yielding 3'-dephospho-CoA and pyrophosphate. Wild-type PPAT from Escherichia coli was purified to homogeneity. chuwi freebook 驅動程式